Triclocarban

Triclocarban (3,4,4′-Trichlorocarbanilide), a broad spectrum antibacterial compound, is widely used in a broad range of applications such as the production of soaps, skin creams, toothpastes and deodorants. Triclocarban is a potential endocrine-disrupting chemical with the capacity to modulate androgen and estrogen activities as well as other hormone-mediated biological processes^[1][2][3]. IC50 & Target: Bacterial^[1] In Vitro: Triclocarban (300 nM) potentiates the cytotoxicity of 300 µM H₂O₂ in rat thymocytes. Triclocarban (300 nM) does not increase the population of death cells, it facilitates the process of cell death induced by H₂O₂, resulting in further increase in the population of dead cells^[1]. Triclocarban exertes estrogenic activities by inducing luciferase activities in an ER reporter gene assay, promoting the proliferation of the MCF-7 cells, up-regulating the expression of pS2 and down-regulating ERα expression at both the mRNA and protein levels in the MCF-7 cells^[2]. In Vivo: Triclocarban is absorbed significantly from soap used during showering in human subjects and that its C_max in their whole blood ranges from 23 nM to 530 nM^[1]. Gestational triclocarban exposure does not affect the ability of dams to carry offspring to term but triclocarban exposure during lactation has adverse consequences on the survival of offspring^[3].