Bis-PEG9-NHS ester


CAS No. : 1008402-79-6

1008402-79-6
Price and Availability of CAS No. : 1008402-79-6
Size Price Stock
25mg $45 In-stock
100mg $59 In-stock
250mg $141 In-stock
1g $283 In-stock
5g $1071 In-stock
25g $3749 In-stock
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100 g Get quote
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Cat. No. : HY-117009
M.Wt: 708.71
Formula: C30H48N2O17
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic)
Introduction of 1008402-79-6 :

Bis-PEG9-NHS ester is a PEG/Alkyl/ether-based PROTAC linker can be used in the synthesis of PROTACs. Bis-PEG9-NHS ester is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[1]. In Vitro: PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

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