Smurf1-IN-A01
CAS No. : 1007647-73-5
(Synonyms: A01)
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $150 | In-stock |
| 25mg | $300 | In-stock |
| 50mg | $490 | In-stock |
| 100mg | $850 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-110195 |
| M.Wt: | 512.93 |
| Formula: | C22H20ClF3N4O3S |
| Purity: | >98 % |
| Solubility: | DMSO : 62.5 mg/mL (ultrasonic) |
Smurf1-IN-A01 is a Smurf1 inhibitor. Smurf1-IN-A01 has anticancer activity and can be used for the research of osteoporosis and age-related macular degeneration[1][2][3][4].
IC50 & Target:Kd: 3.664 nM (Smurf1)[1]
In Vitro:Smurf1-IN-A01 (10 μM, 30-60 min) blocked C-type lectin receptor-2d mediated degradation of MyD88 in RAW264.7 cells upon stimulation with β-glucans[1].
Smurf1-IN-A01 (10 μM, 24 h) attenuates the effect of enhancing the ALP activity and Alizarin red S staining in C3H10T1/2 cells[2].
Smurf1-IN-A01 (10 μM, 12 h) decreases ER alpha protein and ERE-luciferase activity in MCF-7 and T47D cells[3].
In Vivo:Smurf1-IN-A01 (10 μM, 2 μL, Injected into vitreous cavity by micro-syringe, single dose) alleviated retinal injury in retinal degeneration model mice[4].
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