ACT 178882


CAS No. : 1007392-69-9

1007392-69-9
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Cat. No. : HY-U00262
M.Wt: 647.03
Formula: C33H38Cl3N3O4
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 1007392-69-9 :

ACT 178882 is a new Renin inhibitor with an IC50 of 1.4 nM. IC50 & Target: IC50: 1.4 nM (Renin)[1] In Vitro: The median time to Cmax (tmax) for ACT 178882 is prolonged from 3.5 to 5.0 h by diltiazem whereas its apparent terminal half-life (t?) is unaffected by diltiazem, 22.9 and 24.2 h for treatments A and B, respectively. Using treatment A as reference, the geometric mean ratio (90% CI) is 1.62 (1.36 to 1.94) for Cmax and 2.02 (1.75 to 2.34) for AUC, indicating a significant interaction between ACT 178882 and diltiazem[2].

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