AKB-6899
CAS No. : 1007377-55-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $210 | In-stock |
| 10mg | $335 | In-stock |
| 25mg | $580 | In-stock |
| 50mg | $830 | In-stock |
| 100mg | $1180 | In-stock |
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| 500 mg | Get quote | |
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| Cat. No. : | HY-113649 |
| M.Wt: | 290.25 |
| Formula: | C14H11FN2O4 |
| Purity: | >98 % |
| Solubility: | DMSO : 100 mg/mL (ultrasonic) |
AKB-6899, a prolyl hydroxylase domain 3 (PHD3) inhibitor, is a selective HIF-2α stabilizer. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, and has antitumor and antiangiogenic effects[1]. In Vitro: AKB-6899 (10 μM; 24 hours) increases the leves of HIF-2α protein, with no corresponding increase in HIF-1α. AKB-6899 also increases soluble form of the VEGF receptor (sVEGFR-1) production from GM-CSF-treated macrophages, with no effect on HIF-1α accumulation or VEGF production[1]. In Vivo: AKB-6899 (17.5 mg/kg; i.p.; 3 times per week; for 16 days) treatment significantly reduces tumor growth in a murine melanoma model[1].
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