NF546
CAS No. : 1006028-37-0
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| Cat. No. : | HY-108661 |
| M.Wt: | 1180.74 |
| Formula: | C47H44N6Na4O17P4 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
NF546 is a selective non-nucleotide P2Y11 agonist with a pEC50 of 6.27. NF546 stimulates release of interleukin-8 from human monocyte-derived dendritic cells[1]. IC50 & Target: pEC50: 6.27 (P2Y11)[1] In Vitro: NF546 is relatively selective for P2Y11 over P2Y1, P2Y2, P2Y4, P2Y6, P2Y12, P2X1, P2X2, and P2X2-X3. NF546 (100 μM; 24 hours) is equi-efficacious in stimulating TSP-1 release and inhibiting the LPS-induced release of IL-12p70 in human monocyte-derived dendritic cells[1].
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