RG3039 (Standard)
CAS No. : 1005504-62-0
(Synonyms: PF-06687859 (Standard))
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| Cat. No. : | HY-102020R |
| M.Wt: | 432.35 |
| Formula: | C21H23Cl2N5O |
| Purity: | >98 % |
| Solubility: |
RG3039 (Standard) is the analytical standard of RG3039 (HY-102020). This product is intended for research and analytical applications. RG3039 (PF-06687859) is an orally active, blood-brain barrier-permeable DcpS inhibitor with an IC50 of 4.2 nM against hDcpS. RG3039 inhibits the decapping activity of DcpS and maintains DcpS in a catalytically inactive conformation in the central nervous system and other tissues. RG3039 extends survival and improves function in spinal muscular atrophy mice. RG3039 is applicable to research related to spinal muscular atrophy[1][2]. IC50 & Target:IC50: 0.069 nM (DcpS)[1]
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