A12B4C3
CAS No. : 1005129-80-5
| Size | Price | Stock |
|---|---|---|
| 1mg | $228 | In-stock |
| 5mg | $570 | In-stock |
| 10mg | $910 | In-stock |
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| 100 mg | Get quote | |
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| Cat. No. : | HY-100683 |
| M.Wt: | 534.65 |
| Formula: | C30H38N4O5 |
| Purity: | >98 % |
| Solubility: | DMSO : 53 mg/mL (ultrasonic;warming) |
A12B4C3 is a potent human polynucleotide kinase/phosphatase (hPNKP) inhibitor with an IC50 value of 0.06 μM. A12B4C3 has antiproliferative activity against cancer cells. A12B4C3 can also enhance the radiosensitivity of certain cancer cells[1].
IC50 & Target: IC50: 0.06 μM (hPNKP)[1]
In Vitro: A12B4C3 (0-10 μM) strongly inhibits hPNKP phosphatase activity[1].
A12B4C3 (0-100 μM; 72 h) reduces A549 and MDA-MB-231 cell proliferation in a dose dependent manner[1].
A12B4C3 (1 μM; 24 h) increases the radiosensitivity of A549 cells[1].
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