Sterigmatocystine
CAS No. : 10048-13-2
| Size | Price | Stock |
|---|---|---|
| 1mg | $90 | In-stock |
| 5mg | $280 | In-stock |
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| Cat. No. : | HY-N6725 |
| M.Wt: | 324.28 |
| Formula: | C18H12O6 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic;warming;heat to 80°C) |
Sterigmatocystine is a precursor of aflatoxins and a mycotoxin produced by common mold strains from Aspergillus versicolor[1][2]. Sterigmatocystine, a inhibitor of G1 Phase and DNA synthesis, is used to inhibit p21 activity. Sterigmatocystine has teratogenic, and carcinogenic effects in animals[3]. In Vitro: Sterigmatocystine-induced DNA damage activates the ATM/53-dependent signaling pathway, which contributes to the induction of G2 arrest in GES-1 cells[4]. In Vivo: Sterigmatocystine (ip; 3 mg/kg once daily for 14 days) inhibits p21WAF1/CIP1[3].
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