BMS-741672
CAS No. : 1004757-96-3
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| Cat. No. : | HY-108432 |
| M.Wt: | 506.56 |
| Formula: | C25H33F3N6O2 |
| Purity: | >98 % |
| Solubility: |
BMS-741672 is a selective and orally active CCR2 antagonist with an IC50 of 1.1 nM. BMS-741672 shows >700-fold selective for CCR2 than CCR5[1]. In Vitro:BMS-741672 exhibitsan IC50 of 0.67 nM for the inhibition of monocyte chemotaxis in vitro and was fully active in both monkey and hCCR2 knock-in mouse models of monocyte chemotaxis[1]. In Vivo:BMS-741672 is found to have 51% oral bioavailability in a rat with a t1/2 value of 5.1 h (IV), and there is 46% oral bioavailability in a cynomolgus monkey with a t1/2 of 3.2 h (IV)[1].
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