CHF5407
CAS No. : 1004312-94-0
| Size | Price | Stock |
|---|---|---|
| 5mg | $580 | In-stock |
| 10mg | $965 | In-stock |
| 25mg | $2122 | In-stock |
| 50mg | $3183 | In-stock |
| 100mg | $4455 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-U00302 |
| M.Wt: | 613.46 |
| Formula: | C27H25BrF4N2O3S |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CHF5407 is a selective, long-acting and competitive muscarinic M3 receptor antagonist. CHF5407 shows subnanomolar affinities for human muscarinic M1 (hM1), M2 (hM2) and M3 (hM3) receptors. CHF5407 shows a prolonged antibronchospastic activity[1].
IC50 & Target: human muscarinic M1 (hM1), M2 (hM2) and M3 (hM3) receptors[1]
In Vitro: CHF5407 has a very slow dissociation from M3 receptors (hM3; t1/2=166 min) and markedly short-acting at M2 receptors (hM2; t1/2=31 min)[1].
CHF5407 produces a potent (pIC50=9.0-9.6) and long-lasting (up to 24 h) inhibition of M3 receptor-mediated contractile responses to carbachol in the guinea pig isolated trachea and human isolated bronchus[1].
In Vivo: CHF5407 (0.1, 0.3, 1 nmol/kg; intratracheally; 100 ul; sigle dose) exerted a dose-dependent and potent inhibition of ACh-induced (20 g/kg; i.v.) bronchospasm, with an ED50 value of 0.15 nmol/kg in guinea pigs (450-550 g)[1].
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