CP-67015
CAS No. : 100325-51-7
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| Cat. No. : | HY-109855 |
| M.Wt: | 330.29 |
| Formula: | C17H12F2N2O3 |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
CP-67015, a quinolone antibiotic, is a potent topoisomerase II inhibitor. CP-67015 is a positive direct-acting mutagen in mammalian cells with both gene and chromosomal level effects[1].
In Vitro: CP-67015 (10-100 μg/mL; 12-36 h) produces a drastic increase in chromosome damage in human lymphocytes and in CHO cells[1].
CP-67015 inhibits supercoiling activity of prokaryotic DNA gyrase, with 100% inhibition at the concentration of 4.0 μg/mL[1].
In Vivo: CP-67015 (a single dose 1000 mg/kg or 500 mg/kg/day for 5 days; i.p.) induces chromosome damage in male CD-1 mice in mouse bone marrow cells[1].
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