NY0116
CAS No. : 1003000-59-6
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| Cat. No. : | HY-124681 |
| M.Wt: | 345.44 |
| Formula: | C22H23N3O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
NY0116 is a neuromedin U receptor 2 (NMUR2) agonist with EC50 values of 27.76 μM for hNMUR1 and 13.61 μM for hNMUR2. NY0116 decreases cAMP while stimulating calcium signaling in stably expressing NMUR2 HEK293 cells[1]. In Vitro:NY0116 has potent dose-dependent inhibition of cAMP (EC50 of 1.69 nM) in HEK293 cells stably expressing hNMUR2. NY0116 also stimulates calcium signaling in cells[1]. In Vivo:NY0116 (3-30 mg/kg; SC; ; for 14 days) decreases bodyweight, visceral adipose tissue, and cholesterol on a high‐fat diet[1].
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