Methyl azetidine-3-carboxylate (hydrochloride)
CAS No. : 100202-39-9
| Size | Price | Stock |
|---|---|---|
| 5g | $14 | In-stock |
| 10g | $20 | In-stock |
| 25g | $47 | In-stock |
| 100g | $149 | In-stock |
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| Cat. No. : | HY-33615 |
| M.Wt: | 151.59 |
| Formula: | C5H10ClNO2 |
| Purity: | >98 % |
| Solubility: | DMSO : 125 mg/mL (ultrasonic) |
Methyl azetidine-3-carboxylate hydrochloride is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Methyl azetidine-3-carboxylate hydrochloride is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs<
In Vitro: ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1].
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
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- Methyl azetidine-3-carboxylate (hydrochloride)
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