SRT 2183
CAS No. : 1001908-89-9
| Size | Price | Stock |
|---|---|---|
| 5mg | $135 | In-stock |
| 10mg | $220 | In-stock |
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| Cat. No. : | HY-19759 |
| M.Wt: | 468.57 |
| Formula: | C27H24N4O2S |
| Purity: | >98 % |
| Solubility: | DMSO : 250 mg/mL (ultrasonic) |
SRT 2183 is a selective Sirtuin-1 (SIRT1) activator with an EC1.5 value of 0.36 μM[1]. SRT 2183 induces growth arrest and apoptosis, concomitant with deacetylation of STAT3 and NF-κB, and reduction of c-Myc protein levels[2].
IC50 & Target: EC1.5: 0.36 μM (SIRT1)[1]
In Vitro: SRT 2183 (1-10 μM; 24-72 hours) inhibits the growth of Reh and Nalm-6 cells in a time- and dose-dependent manner[2].
SRT 2183 (5-10 μM in Reh cells; 10 μM in Ly3 cells; 24 hours) induces expression of DNA-damage response genes associated with accumulation of phospho-H2A.X levels[2].
SRT2183 inhibits RANKL-induced osteoclast differentiation, fusion and resorptive capacity without affecting osteoclast survival[3].
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