BV6
CAS No. : 1001600-56-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $56 | In-stock |
| 5mg | $119 | In-stock |
| 10mg | $190 | In-stock |
| 25mg | $380 | In-stock |
| 50mg | $608 | In-stock |
| 100mg | $970 | In-stock |
| 200 mg | Get quote | |
| 500 mg | Get quote | |
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| Cat. No. : | HY-16701 |
| M.Wt: | 1205.57 |
| Formula: | C70H96N10O8 |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL |
BV6 is an antagonist of cIAP1 and XIAP, members of the inhibitors of apoptosis (IAP) family. BV6 shows an IC50 of 7.2 μM in MTS assays in HCC193 cells. BV6 can be used in the research of endometrial cancer and endometriosis[1][2].
IC50 & Target:IAP[1]
In Vitro:BV6 (250 nM-30 μM, 24 h) induces apoptosis in HCC193 and H460 lung cancer cell lines in a concentration- and time-dependent manner. BV6 can also enhance the sensitivity of HCC193 and H460 cell lines to radiation[1].
BV6 (1μM 24 h; 5 μM, 48 h) significantly sensitizes the cell to radiation (HCC193-DER=1.38, at 1 μM BV6; H460-DER=1.42, at 5 μM BV6)[1].
In Vivo:BV6 (10 mg/kg, twice weekly for 4 weeks, i.p.) attenuated the intensity of IAPs expression[2].
BV6 (10 mg/kg, twice weekly for 4 weeks, i.p.) reduces the total number of lesions and the percentage of Ki67-positive cells compared to the control[2].
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