CORM-401
CAS No. : 1001015-18-4
| Size | Price | Stock |
|---|---|---|
| 5mg | $90 | In-stock |
| 10mg | $145 | In-stock |
| 50mg | $475 | In-stock |
| 100mg | $620 | In-stock |
| 250mg | $930 | In-stock |
| 500 mg | Get quote | |
| 1 g | Get quote | |
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| Cat. No. : | HY-109804 |
| M.Wt: | 331.20 |
| Formula: | C8H6MnNO6S2 |
| Purity: | >98 % |
| Solubility: | DMSO : 25 mg/mL (ultrasonic) |
CORM-401 is an oxidant-sensitive CO-releasing molecule. CORM-401 induces NO increase in the regulation of endothelial calcium signalling. CORM-401 reduces TNF-α/CHX and H2O2-induced ROS production. CORM-401 uncouples mitochondrial respiration and inhibits glycolysis[1][2][3].
In Vitro: CORM-401 (100 µM; 1h) induces the NO production in endothelial EA.hy926 cells[1].
CORM-401 (30 µM) induces peak-like calcium signal and augmentes coupling of endoplasmic reticulum and plasmalemmal store-operated calcium channels[1].
CORM-401 (50 µM; 1h) significantly reduces TNF-α/CHX and H2O2-induced ROS production and cell death[2].
CORM-401 (0.5, 1 mM) induces a persistent increase in the oxygen consumption rate in endothelial EA.hy926 cells[3].
CORM-401 (10, 30, 100 µM) induces a concentration-dependent increase in OCR and a simultaneous decrease in ECAR[3].
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