Pimecrolimus (hydrate)
CAS No. : 1000802-56-1
(Synonyms: SDZ-ASM 981 (hydrate))
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| 10mg | $66 | Get quote |
| 50mg | $99 | Get quote |
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| Cat. No. : | HY-13723A |
| M.Wt: | 1000.00 |
| Formula: | C43H68ClNO11.xH2O |
| Purity: | >98 % |
| Solubility: | 10 mM in DMSO |
Pimecrolimus hydrate (SDZ-ASM 981 hydrate) is a potent, nonsteroid and orally active calcineurin inhibitor. Pimecrolimus hydrate shows anti-inflammatory activity. Pimecrolimus hydrate has the potential for the research of atopic dermatitis and oral erosive lichen planus[1][2][3]. In Vitro: Pimecrolimus hydrate (100 nM) targets T-cells and mast cells and inhibits the production and release of cytokines and other inflammatory mediators, as well as the expression of signals essential for the activation of inflammatory T-lymphocytes[1]. In Vivo: Pimecrolimus hydrate (10, 30 mg/kg; p.o.; daily for 4 weeks) increases in absolute numbers of T lymphocytes in KLH-immunised rats compared with non-immunised animals[2].
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