THPN


CAS No. : 100079-26-3

100079-26-3
Price and Availability of CAS No. : 100079-26-3
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Cat. No. : HY-113827
M.Wt: 266.33
Formula: C15H22O4
Purity: >98 %
Solubility: 10 mM in DMSO
Introduction of 100079-26-3 :

THPN is a potent Nur77 agonist. THPN specifically binds the LBD of Nur77 (TR3) but not that of retinoic acid receptor α and PPARγ with a Kd of 270 nM. THPN leads to Nur77 translocation to the mitochondria to induce autophagic cell death in melanoma[1][2].

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