INT-767
CAS No. : 1000403-03-1
| Size | Price | Stock |
|---|---|---|
| 1mg | $280 | In-stock |
| 5mg | $700 | In-stock |
| 10mg | $1100 | In-stock |
| 50mg | $3320 | In-stock |
| 100 mg | Get quote | |
| 200 mg | Get quote | |
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| Cat. No. : | HY-12434 |
| M.Wt: | 494.66 |
| Formula: | C25H43NaO6S |
| Purity: | >98 % |
| Solubility: | DMSO : ≥ 100 mg/mL;H2O : 100 mg/mL (ultrasonic) |
INT-767 is a dual farnesoid X receptor (FXR)/TGR5 agonist with mean EC50s of 30 and 630 nM, respectively[1][2]. In Vitro: INT-767 does not show cytotoxic effects in HepG2 cells, does not inhibit cytochrome P450 enzymes, is highly stable to phase I and II enzymatic modifications, and does not inhibit the human ether-a-go-go-related gene potassium channel[2]. In Vivo: INT-767 (10-20 mg/kg; i.p.; daily for 2 weeks) decreases plasma total cholesterol and triglyceride levels in db/m and db/db mice [2].
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