Cyclamic acid


CAS No. : 100-88-9

(Synonyms: Cyclohexylsulfamic acid; Cyclamate)

100-88-9
Price and Availability of CAS No. : 100-88-9
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Cat. No. : HY-B0541
M.Wt: 179.24
Formula: C6H13NO3S
Purity: >98 %
Solubility: DMSO : 100 mg/mL (ultrasonic);H2O : ≥ 100 mg/mL
Introduction of 100-88-9 :

Cyclamic acid (Cyclamate) is a commonly used sweetener. Cyclamic acid sodium is toxic to osteoblasts and can inhibit cell proliferation, induce apoptosis and reduce cell mineralization. Cyclamic acid sodium causes focal necrosis of bladder organs in rats in vitro, which can promote bladder cancer, but some studies have shown that low doses of Cyclamic acid sodium have no carcinogenic effect. In addition, Cyclamic acid sodium has no effect on insulin and glucagon secretion induced by arginine[1][2][3][4][5]. In Vitro:Cyclamic acid (0-0.1 μM, 24-72 h) causes the apoptosis of osteoblast cells and shows significant inhibition of osteoblasts[2].
In Vivo:Cyclamic acid (2-4 g/kg, p.o., daily for 2 weeks) occurs diarrhea in dogs[3].

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